Protein Details: Potassium voltage-gated channel subfamily KQT member 3
Protein ID
ICDB_Pro_0283
Protein Name
Potassium voltage-gated channel subfamily KQT member 3
Gene Name
Kcnq3
Organism
Rattus norvegicus (Rat)
Length
873 amino acids
AlphaFoldDB
AF-O88944-F1-model_v4.pdb
Function
Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current; a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore; it is important in the regulation of neuronal excitability. KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium; in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity; increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity)
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Expressed in brain and sympathetic ganglia. In brain; expressed in cortex; hippocampus and at much lower levels in cerebellum. In sympathetic ganglia; expressed at approximately equal levels in both superior cervical ganglia and prevertebral ganglia.
DOI ID
10.1126/science.282.5395.1890; 10.1038/ncomms1871; 10.1074/jbc.m116.758029
RefSeq
NP_113785.3 [O88944-1]